Surgical removal of the lump or cancer cells (lumpectomy) or mastectomy is still the main treatment for breast cancer. It is often combin with radiation therapy. Which is delivere to the surgical site to destroy any remaining cancer cells. Chemotherapy and targeted drugs may given both before surgery to reduce the size of the tumor and after surgery to prevent spread and recurrence. However, in recent years, new drugs called ‘targeted drugs’ have developed and invented, making them a new treatment option that offers many benefits.
What is Targeted Therapy ?
At present, we have found. That each type of cancer cell has its own characteristics from different gene mutations, which affect cell division for growth, including evading the body’s immune system and creating new blood vessels of the cancer cells themselves. Targeted therapy has develop to have the ability to inhibit and destroy various processes that are specific to the mechanisms that cancer cells use to grow and spread. In addition to increasing the chances of treatment. It also improves the quality of life of patients from fewer side effects than using traditional drugs or chemotherapy and radiation therapy. Targeted drugs are available in both oral and injectable forms.
Benefits and mechanisms of action of targeted therapy in cancer treatment
- It helps inhibit the function of the cancer cell pathway or cell division pathway, causing cancer cells to stop expanding and stop rapid spreading. It is a more targeted way to eliminate cancer cells than chemotherapy alone.
- Helps the immune system more effectively identify and destroy cancer cells that evade detection.
- It helps stop the process of creating new blood vessels (Angiogenesis). That feeds cancer cells, allowing the cancer cells to receive more chemotherapy and stop their growth.
- Helps stimulate the process of destroying abnormal cells or cancer cells. That avoid being destroyed by the natural process of cell destruction (Apoptosis).
Although targeted therapy does not reduce the side effects of chemotherapy. It may also cause some symptoms, such as skin symptoms such as rashes, dry skin, itching, nail edge inflammation, or gastrointestinal symptoms such as nausea, เว็บพนันออนไลน์ UFABET สมัครง่าย โปรโมชั่นมากมาย vomiting, loss of appetite, diarrhea, constipation, as well as other symptoms such as reduced immunity, low white blood cell count, abnormal blood clotting, slow wound healing, fatigue, high blood pressure, hair loss, etc.
Targeted Therapy for Breast Cancer
The appropriate and effective use of targeted drugs must be consistent with the genetic material of the cancer cells detected, such as:
- Treatment of HER2-positive breast cancer
HER2-positive breast cancer accounts for approximately 20% of all patients. Having a high level of HER2 (Human Epidermal Growth Factor Receptor 2) protein allows cancer cells to grow and spread rapidly. The targeted drugs Trastuzumab, Pertuzumab, and Lapatinib effectively inhibit the HER2 protein and reduce cancer cell division. In addition, the drugs T-DM1 and Trastuzumab deruxtecan help the chemotherapy used in combination treatment to directly target cancer cells with HER2, thus reducing side effects more than using conventional drugs. It can also use in both early-stage and metastatic breast cancer patients, prolonging the patient’s life, reducing the chance of recurrence. After surgery, and increasing the chance of a complete cure in some cases.
- Treatment of hormone receptor-positive (HR+) and HER2-negative breast cancer
Palbociclib, Ribociclib, and Abemaciclib are used to treat hormone receptor-positive (HR+) and HER2-negative breast cancers by inhibiting CDK4 and CDK6. Which play important roles in controlling cancer cell division. This is especially true in hormone-positive breast cancer, where cancer cells require hormones to grow. Treatment is often combine with hormone therapy. Can use in both early-stage and HER2-negative breast cancers.