Researchers have found that PCOS (polycystic ovary syndrome) occurs majorly because of the hormonal imbalance prior to the birth and it is also the most common cause of infertility in women.
As per a New Scientist report, the scientists successfully cured the condition in mice, and a clinical test on a human is still due, which can start in the late quarter of the year. The report said, “1 out of every 5 women experiences PCOS in all over the world.”
The condition impacts the functioning of woman’s ovaries, which has the symptoms of difficulty in conceiving and irregular period. Robert Norman, told the New Scientist, in University of Adelaide, Australia, “It is the most common cause of infertility in women, affecting them during reproduction process, but it hasn’t still got the attention, it should have.”
A team of researchers at the French National Institute of Health and Medical Research reported that the condition gets triggered prior to the birth by getting excessive exposure to the mother’s womb to a genome referred as “AMH” (Anti-Müllerian hormone).
They found that women suffering from PCOS experience 30% higher hormone levels during pregnancy compared to their non-pregnant counterpart. As the issue is a hereditary condition, researchers are hoping to test the concept that hormonal imbalance during pregnancy can persuade the same medical condition in daughters as well.
Scientists have infused the Anti-Müllerian hormone in the pregnant mice, and as the baby grew up, they found that mice experience many symptoms of PCOS, which includes irregular periods and difficulty in conceiving a child.
The excess amount of AHM hormone seemed to cause the overstimulation of the cells in the nervous system, which increases the testosterone levels. After using “Cetrorelix”, an IVF drug, utilized to control hormones in women, the injected mice stopped displaying any symptoms of PCOS.
Paolo Giacobini, head of research, told the New Scientist, “It could be an effective way to reinstate regularity in ovulation and improve the rate of pregnancy.”