As per the study from Vanderbilt Memory and Alzheimer’s Center, the gene known as APOE is the biggest chronic risk element for Alzheimer’s. It has a crucial role in developing the disorder in women more than men.
The study has affirmed that APOE ε4 factor is associated with the Alzheimer and impacting more women compared to men, and took the research a step ahead by identifying its relation with the tau levels and amyloid.
The study issued in JAMA Neurology on May 7 backed the fact that the longer longevity is not the only reason behind the finding of women with high vulnerability to Alzheimer than men. Almost 65% of Alzheimer patients in the US are women.
Assistant Prof. of Neurology, Dr. Timothy J. Hohman, leading the research said, “The study is grounded on a meta-analysis of six datasets of autopsy test results of brains diagnosed with Alzheimer as well as four datasets of research volunteers’ CSF (cerebral spinal fluid).”
The findings are the most accurate till date that APOE genome has a crucial part in developing Alzheimer in women compared to men. Hohman added, “There is not enough research done by anyone to measure whether individual’s sex could be a factor in Alzheimer’s disorder.”
The research analyzed, does APOE is women and men was related to the Tau pathway or Amyloid pathway. The study revealed, “The link of the amyloid pathway was similar in women and men. However, the link between APOE and tau pathway was strong in women.”
Hohman said, “It is opposite of what we were thinking because APOE has a significant part in processing amyloid.”
The author wrote, “The research is heading in the direction of considering person’s sexual orientation as a variable in the analysis.” This can help us to identify that what is the ideal way of approaching to treat Alzheimer’s in individuals of different age group and sexual orientation.